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( A ) The schematic protocol for anti–IL-6 treatment. ( B ) Ankle thickness after the intervention. ( C ) Ankle thickness at day 24. ( D ) Representative histology. ( E ) Cumulative data of the histological score. (B to E) N = 7 to 11 from four independent experiments. ( F ) The potential to flare arthritis by IL-6. The illustration shows how the mice were treated. ( G ) Ankle thickness after the intervention. ( H ) Ankle thickness at day 24. ( I ) Representative histology. ( J ) Cumulative data of the histological score. (G to J) N = 8 to 9 from two independent experiments. P values were determined by unpaired t test.

Journal: Science Advances

Article Title: Fibroblast-like synoviocytes exacerbate autoimmune arthritis upon psychological stress in an IL-6–dependent manner

doi: 10.1126/sciadv.aec9257

Figure Lengend Snippet: ( A ) The schematic protocol for anti–IL-6 treatment. ( B ) Ankle thickness after the intervention. ( C ) Ankle thickness at day 24. ( D ) Representative histology. ( E ) Cumulative data of the histological score. (B to E) N = 7 to 11 from four independent experiments. ( F ) The potential to flare arthritis by IL-6. The illustration shows how the mice were treated. ( G ) Ankle thickness after the intervention. ( H ) Ankle thickness at day 24. ( I ) Representative histology. ( J ) Cumulative data of the histological score. (G to J) N = 8 to 9 from two independent experiments. P values were determined by unpaired t test.

Article Snippet: For TNF and IL-1β blocking, the same protocol was used, except that either 200 μg of polyclonal Armenian hamster IgG (BioXCell) or anti–IL-1β antibody (B122, BioXCell) was intraperitoneally injected.

Techniques: Histology